Shoc2蛋白

Author: nssm

August undefined, 2024

WebSrc Homolgy-2磷酸酶(SHP2)是PTPN11基因所编码的非受体蛋白酪氨酸磷酸酶，其促进多种细胞功能，包括增殖、分化、细胞周期维持和迁移。 SHP2牵涉在经由Ras-有丝分裂原-激活的蛋白激酶、JAK–STAT或磷酸肌醇3-激酶-AKT途径的信号传导中。 Web10 Jun 2024 · SHOC2 inhibition perturbs tumour growth in lung cancer models. To study the in vivo role of SHOC2 we have developed two mouse models of SHOC2 inactivation using Knock-out (KO) or Knock-in (KI ...

SHOC2 phosphatase-dependent RAF dimerization mediates

WebPPP2R1B 蛋白质磷酸酶2调节亚基1B抗体 0.2ml PPP2R3A 蛋白质磷酸酶2调节亚基3A抗体 0.2ml SHOC2/Sur8 富含亮氨酸重复蛋白SHOC2抗体 0.2ml RAMP/CDT2 维甲酸调节核基质相关蛋白 0.2ml MTMR8 肌管素相关蛋白8抗体 0.2ml NIFK KI67相互作用蛋白抗体 0.2ml Web29 Jun 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS11–13, but the structure of SHOC2 and the … cable flash

New protein complex structure reveals possible ways to target key …

Web13 Jul 2024 · A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to ... WebSHOC2 has been shown to interact with the catalytic phosphatase subunit PP1C(PMID 16630891) and MRAS as well as canonical RAS isoforms (H/K/NRAS)(PMID 35768504, 35831509, 35830882). The ternary complex SHOC2-RAS-PP1C functions to dephosphorylate an inhibitory phosphorylation site ('S259') on RAF family proteins to enable MAPK … Web24 Feb 2024 · 在人细胞中，SHOC2是一种加速ERK1/2信号转导的支架蛋白，而从寄生虫到哺乳动物，SHOC2均高度保守。基于此，研究者进一步探讨，Erk是否参 … cable flashing

SHOC2 癌基因 - 癌症123

WebThe potential SHOC2 inhibitor celastrol phenocopied SHOC2 depletion. In addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR-TKIs in … Web8 Jul 2024 · The authors identified a heterozygous mutation (S2G; 602775.0001) in the SHOC2 gene in 4 unrelated individuals. They then analyzed the SHOC2 gene in a cohort of … cable fish lineWeb21 Mar 2024 · SHOC2 (SHOC2 Leucine Rich Repeat Scaffold Protein) is a Protein Coding gene. Diseases associated with SHOC2 include Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 and Noonan Syndrome-Like Disorder With Loose Anagen Hair . Among its related pathways are RAF/MAP kinase cascade and Signaling by MRAS-complex mutants . club walker

"Web27 Jul 2024 · Based on a systems biology approach that identified SHOC2 as a candidate gene, Cordeddu et al. (2009) sequenced SHOC2 coding exons in a Noonan syndrome cohort that included 96 individuals who were negative for mutations in known disease genes and identified a heterozygous mutation (S2G; 602775.0001) in 4 unrelated individuals.They … " - Shoc2蛋白

Shoc2蛋白

Entry - *602775 - SHOC2 LEUCINE-RICH REPEAT SCAFFOLD …

WebSHOC2. （SHOC2 leucine rich repeat scaffold protein）. 这个基因编码一种几乎完全由富含亮氨酸重复序列组成的蛋白质，这是一个与蛋白质相互作用有关的结构域在RAS/ERK … Web30 Sep 2010 · Mutation analysis in patients and development of a rapid mutation detection system. Sequence analysis of all coding regions of SHOC2 in 92 patients revealed a c.4A>G mutation (p.S2G) in exon1 of ...

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Web4 Feb 2024 · DOI: 10.1038/s41594-022-00841-4. Primary Citation of Related Structures: 7TVF, 7TVG. PubMed Abstract: SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by ... Web丁香通为您提供IL34Antibody商品详情介绍：价格：询价，货号：LBP70500，品牌：Leading Biology，产地：美国，详见丁香通IL34Antibody商品详情页；

Web21 Jun 2013 · Shoc2 is a positive regulator of signaling to extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). Shoc2 is also proposed to interact with RAS and Raf-1 in order to accelerate ERK1/2 activity. To understand the mechanisms by which Shoc2 regulates ERK1/2 activation by the epidermal growth factor receptor (EGFR), we dissected … Web29 Sep 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating ...

Web20 Jun 2001 · R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function; R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling; SIGNOR. Q9UQ13; SignaLink. Q9UQ13; Names & Taxonomy. Protein names. Recommended name. Leucine-rich repeat protein SHOC-2. Alternative names. Protein soc-2 homolog; Protein sur-8 homolog; … Web13 Jul 2024 · The SHOC2–MRAS–PP1C holophosphatase complex functions as a key regulator of RTK–RAS signalling by removing an inhibitory phosphorylation event on the …

Web10 Jun 2024 · The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on RAF kinases.

Web29 Jun 2024 · shoc2是一个重要的支架蛋白，它与pp1c和ras一起参与raf ntps11的去磷酸化，但shoc2的结构和推定的shoc2-pp1c-ras复合物的结构仍然未知。 club wall lightWebshoc2 是一种包含多个亮氨酸富集串联重复序列的支架蛋白，同时也是生长因子依赖性 mapk/erk 信号转导的一个上游正调节分子。研究表明，SHOC2 与 PP1 磷酸酶和 M-Ras 的 … cable fleece lined leggingsWeb3 Oct 2024 · This is achieved by PP1, whose specificity for RAF is conferred by the dual action of the scaffold protein SHOC2 and a second small GTPase, M-RAS. Four new structures, three published in Nature ... club walletsWeb采集先证者及其父母外周血，提取基因组dna行全外显子组测序，结果显示，先证者shoc2基因2号外显子存在c.4a>g错义突变，导致第2号氨基酸由丝氨酸变为甘氨酸（p.s2g），患儿父母未检出该突变。结合临床表型与基因突变，确诊为努南样综合征伴生长期毛发松动。 cable flex gymWeb酶联生物为您提供大鼠生长停滞dna损伤可诱导蛋白α(gadd45α)检测试剂盒的参数及2024年最新报价，厂家专业的大鼠生长停滞dna损伤可诱导蛋白α(gadd45α)检测试剂盒售后服务团队，是您值得信赖的合作伙伴 club walserbergWeb10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high … clubware contactWebLeucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of SHOC2 is in modulating signals of the extracellular … clubware app download